Rapid Assembly of Saturated Nitrogen Heterocycles in One-Pot: Diazo-Heterocycle “Stitching” by N-H Insertion and Cyclization was written by Boddy, Alexander J.;Affron, Dominic P.;Cordier, Christopher J.;Rivers, Emma L.;Spivey, Alan C.;Bull, James A.. And the article was included in Angewandte Chemie, International Edition in 2019.HPLC of Formula: 587-88-2 This article mentions the following:
Methods that provide rapid access to new heterocyclic structures in biol. relevant chem. space provide important opportunities in drug discovery. Here, a strategy is described for the preparation of 2,2-disubstituted azetidines, pyrrolidines, piperidines, and azepanes bearing ester and diverse aryl substituents. A one-pot rhodium catalyzed N-H insertion and cyclization sequence uses diazo compounds to stitch together linear 1,m-haloamines (m = 2-5) to rapidly assemble 4-, 5-, 6-, and 7-membered saturated nitrogen heterocycles in excellent yields. Over fifty examples are demonstrated, including examples with diazo compounds derived from biol. active compounds The products can be functionalized to afford α,α-disubstituted amino acids and applied to fragment synthesis. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2HPLC of Formula: 587-88-2).
Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.HPLC of Formula: 587-88-2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics