The total synthesis of chlorophyll a was written by Woodward, Robert Burns;Ayer, William A.;Beaton, John M.;Bickelhaupt, Friedrich;Bonnett, Raymond;Buchschacher, Paul;Closs, Gerhard L.;Dutler, Hans;Hannah, John. And the article was included in Tetrahedron in 1990.Safety of Ethyl 4-methyl-1H-pyrrole-3-carboxylate This article mentions the following:
The total synthesis of chlorophyll a starting Knorr’s pyrrole (I) is described with full exptl. detail. Forty six stages are involved to reach the target mol., chlorin e6 tri-Me ester (II) from which chlorophyll a has already been prepared The four pyrroles which are required for rings A, B, C and D are elaborated largely by known reactions, although with considerable improvements. These pyrroles are manipulated to give two dipyrrin derivatives These are brought together in a carefully controlled, stepwise, condensation to give a single porphyrin product in 50% yield. Eleven steps complete the synthesis. In the experiment, the researchers used many compounds, for example, Ethyl 4-methyl-1H-pyrrole-3-carboxylate (cas: 2199-49-7Safety of Ethyl 4-methyl-1H-pyrrole-3-carboxylate).
Ethyl 4-methyl-1H-pyrrole-3-carboxylate (cas: 2199-49-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Safety of Ethyl 4-methyl-1H-pyrrole-3-carboxylate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics