Synthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease was written by Mugnaini, Claudia;Rabbito, Alessandro;Brizzi, Antonella;Palombi, Nastasja;Petrosino, Stefania;Verde, Roberta;Di Marzo, Vincenzo;Ligresti, Alessia;Corelli, Federico. And the article was included in European Journal of Medicinal Chemistry in 2019.Safety of Methyl 2-aminonicotinate This article mentions the following:
A set of CB2R ligands, based on the thiophene scaffold, was synthesized and evaluated in in vitro assays. Compounds bearing the 3-carboxylate and 2-(adamantan-1-yl)carboxamido groups together with apolar alkyl/aryl substituents at 5-position or at 4- and 5-positions of the thiophene ring possess high CB2R affinity at low nanomolar concentration, good receptor selectivity, and agonistic functional activity. The full agonist Me 2-[((adamantan-1-yl)carbonyl)amino]-4-ethyl-5-methylthiophene-3-carboxylate , showing the best balance between receptor affinity and selectivity, was tested in vitro in an exptl. model of allergic contact dermatitis and is able to block the release of MCP-2 in HaCaT cells at 10 μM concentration In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Safety of Methyl 2-aminonicotinate).
Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Safety of Methyl 2-aminonicotinate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics