Synthesis and anticancer evaluation of 3-substituted quinolin-4-ones and 2,3-dihydroquinolin-4-ones was written by Rajput, Santosh;Gardner, Christopher R.;Failes, Timothy W.;Arndt, Greg M.;Black, David StC.;Kumar, Naresh. And the article was included in Bioorganic & Medicinal Chemistry in 2014.Application of 587-88-2 This article mentions the following:
A series of 3-aryl-5,7-dimethoxyquinolin-4-ones I [R1 = Ph, 4-BrC6H4, 4-MeC6H4, etc.] and 3-aryl-5,7-dimethoxy-2,3-dihydroquinolin-4-ones II [ R2 = Ph, 4-BrC6H4, 4-MeC6H4, etc.] were synthesized in good yields. Demethylation under a range of conditions afforded the corresponding 5-hydroxy and 5,7-dihydroxy derivatives Biol. evaluation against a range of cancer cells lines showed that the quinolin-4-one scaffold was more cytotoxic than the reduced 2,3-dihydroquinolin-4-one scaffold. The most active monohydroxy compound demonstrated 85.9-99% reduction in cell viability against the cell lines tested. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Application of 587-88-2).
Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Application of 587-88-2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics