Copper nanoparticles on controlled pore glass (CPG) as highly efficient heterogeneous catalysts for “click reactions” was written by Rafi, Abdolrahim A.;Ibrahem, Ismail;Cordova, Armando. And the article was included in Scientific Reports in 2020.Safety of (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate This article mentions the following:
Herein, the supported copper nanoparticles (CuNPs) on com. available controlled pore glass (CPG), which exhibit high mech., thermal and chem. stability as compared to other silica-based materials, serve as a useful heterogeneous catalyst system for 1,3-dipolar cycloadditions (“click” reactions) between organic azides RCH2N3 (R = Ph, pentadecyl, (5S)-1-[methoxycarbonyl]-5-[(tert-butoxy)carbonyl]pyrrolidin-3-yl) and terminal alkynes HCCR1 (R1 = hydroxymethyl, 4-methoxyphenoxymethyl, ([(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy)methyl, etc.) under green chem. conditions. The supported CuNPs-CPG catalyst exhibited a broad substrate scope and gave the corresponding triazole products I in high yields. The CuNPs-CPG catalyst exhibit recyclability and could be reduced multiple times without contaminating the products with Cu. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4Safety of (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate).
(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Safety of (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics