Click chemistry-based synthesis and cytotoxic activity evaluation of 4α-triazole acetate podophyllotoxin derivatives was written by Hou, Wei;Zhang, Guanjun;Luo, Zhi;Su, Lin;Xu, Hongtao. And the article was included in Chemical Biology & Drug Design in 2019.Application In Synthesis of tert-Butyl (3-ethynylphenyl)carbamate This article mentions the following:
A series of novel 4α-triazole acetate podophyllotoxin derivatives were synthesized via click chem. In vitro cytotoxic activity evaluation showed that most of the derivatives exhibited potent inhibitory activities against the tested cancer cell lines with low nanomolar IC50 values. Further studies demonstrated that compound I exhibited broad-spectrum cytotoxic activities, effectively overcame drug-resistance, and showed relatively weak cytotoxicity on non-cancer cells. Preliminary mechanistic studies indicated that I might have action on microtubule, cause cell cycle arrest at G2/M phase, and induce apoptosis in human PC-3 cancer cells. In the experiment, the researchers used many compounds, for example, tert-Butyl (3-ethynylphenyl)carbamate (cas: 185619-66-3Application In Synthesis of tert-Butyl (3-ethynylphenyl)carbamate).
tert-Butyl (3-ethynylphenyl)carbamate (cas: 185619-66-3) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application In Synthesis of tert-Butyl (3-ethynylphenyl)carbamate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics