Synthesis of polyorganophosphazenes and fabrication of their blend microspheres and micro/nanofibers as drug delivery systems was written by Ullah Khan, Rizwan;Wang, Li;Yu, Haojie;Zain-Ul-Abdin;Haq, Fazal;Haroon, Muhammad;Naveed, Kaleem-Ur-Rehman;Elshaarani, Tarig;Fahad, Shah;Ren, Sicong;Wang, Jun. And the article was included in International Journal of Polymeric Materials and Polymeric Biomaterials in 2020.Formula: C9H10O3 This article mentions the following:
Four amino acid-based polyorganophosphazenes were synthesized and characterized by 1H NMR, 31P NMR and GPC. Individually, the synthesized polyorganophosphazenes were blended with two commonly used biocompatible polymers, poly (Me methacrylate) (PMMA) and polylactic-co-glycolic acid (PLGA) to fabricate anticancer drug loaded micro/nanofibers and microspheres. The nature of side groups, blend composition and drug contents were particularly found significant to adjust the surface morphol., hydrolytic degradation and drug loading/release behavior of microspheres. Moreover, higher in vitro drug release rate was observed in acidic medium. Collectively, our findings suggest that amino acid-based polyorganophosphazenes blend’ systems may provide a therapeutic strategy for cancers. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxybenzoate (cas: 118-61-6Formula: C9H10O3).
Ethyl 2-hydroxybenzoate (cas: 118-61-6) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Formula: C9H10O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics