Synthesis and Structure-Activity Relationship Studies of Benzo[b][1,4]oxazin-3(4H)-one Analogues as Inhibitors of Mycobacterial Thymidylate Synthase X was written by Modranka, Jakub;Li, Jiahong;Parchina, Anastasia;Vanmeert, Michiel;Dumbre, Shrinivas;Salman, Mayla;Myllykallio, Hannu;Becker, Hubert F.;Vanhoutte, Roeland;Margamuljana, Lia;Nguyen, Hoai;Abu El-Asrar, Rania;Rozenski, Jef;Herdewijn, Piet;De Jonghe, Steven;Lescrinier, Eveline. And the article was included in ChemMedChem in 2019.Related Products of 16413-26-6 This article mentions the following:
Since the discovery of a flavin-dependent thymidylate synthase (ThyX or FDTS) that is absent in humans but crucial for DNA biosynthesis in a diverse group of pathogens, the enzyme has been pursued for the development of new antibacterial agents against Mycobacterium tuberculosis, the causative agent of the widespread infectious disease tuberculosis (TB). In response to a growing need for more effective anti-TB drugs, we have built upon our previous screening efforts and report herein an optimization campaign of a novel series of inhibitors with a unique inhibition profile. The inhibitors display competitive inhibition toward the methylene tetrahydrofolate cofactor of ThyX, enabling us to generate a model of the compounds bound to their target, thus offering insight into their structure-activity relationships. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Related Products of 16413-26-6).
3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Related Products of 16413-26-6
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics