A DNA-derived phage nose using machine learning and artificial neural processing for diagnosing lung cancer was written by Lee, Jong-Min;Choi, Eun Jeong;Chung, Jae Heun;Lee, Ki-wook;Lee, Yujin;Kim, Ye-Ji;Kim, Won-Geun;Yoon, Seong Hoon;Seol, Hee Yun;Devaraj, Vasanthan;Ha, Jong Seong;Lee, Donghan;Kwon, Sang-Mo;Kim, Yun Seong;Chang, Chulhun L.;Oh, Jin-Woo. And the article was included in Biosensors & Bioelectronics in 2021.Application of 695-06-7 This article mentions the following:
There is a growing interest in electronic nose-based diagnostic systems that are fast and portable. However, existing technologies are suitable only for operation in the laboratory, making them difficult to apply in a rapid, non-face-to-face, and field-suitable manner. Here, we demonstrate a DNA-derived phage nose (D2pNose) as a portable respiratory disease diagnosis system requiring no pretreatment. D2pNose was produced based on phage color films implanted with DNA sequences from mammalian olfactory receptor cells, and as a result, it possesses the comprehensive reactivity of these cells. The manipulated surface chem. of the genetically engineered phages was verified through a correlation anal. between the calculated and the exptl. measured reactivity. Breaths from 31 healthy subjects and 31 lung cancer patients were collected and exposed to D2pNose without pretreatment. With the help of deep learning and neural pattern separation, D2pNose has achieved a diagnostic success rate of over 75% and a classification success rate of over 86% for lung cancer based on raw human breath. Based on these results, D2pNose can be expected to be directly applicable to other respiratory diseases. In the experiment, the researchers used many compounds, for example, 5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7Application of 695-06-7).
5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application of 695-06-7
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics