Discovery of contaminants with antagonistic activity against retinoic acid receptor in house dust was written by Jia, Yingting;Zhang, Hong;Hu, Wenxin;Wang, Lei;Kang, Qiyue;Liu, Jiaying;Nakanishi, Tsuyoshi;Hiromori, Youhei;Kimura, Tomoki;Tao, Shu;Hu, Jianying. And the article was included in Journal of Hazardous Materials in 2022.Application In Synthesis of Dimethyl decanedioate This article mentions the following:
Retinoic acid receptors (RARs) control reproduction and development in vertebrates, but little attention has been paid to anthropogenic chems. exhibiting RAR agoniztic/antagonistic activity. Here we applied a His-RARα pull-down assay combined with high-resolution mass spectrometry to identify chems. with RARα activity in house dust. After screening, a total of 540 peaks were retained as potential RARα ligands. The mass spectra of 14 chems. matched with those in the database, of which tri-Ph phosphate, galaxolidone, di(2-ethylhexyl) phthalate (DEHP), tris(2-ethylhexyl) phosphate (TEHP), and tris(2-butoxyethyl) phosphate were confirmed by their standards While one chem. in the sample matched with monophenyl phosphate in the MS/MS database, its retention time was much higher than that of monophenyl phosphate standard, suggesting that it may be an in-source fragment. Its parent ion was finally identified to be m/z 399.2663 using a similarity anal. among chromatog. peaks of hundreds of ions at the same retention time in MS1 spectrum, and bis(2-ethylhexyl) Ph phosphate (BEHPP) was identified. BEHPP, DEHP, and TEHP were for the first time identified to be RARα antagonists with IC50 values of 6556, 6600, and 2538 nM, resp. This study improved structural annotation and filled the knowledge gap regarding widespread environmental contaminants with RAR antagonistic activity. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Application In Synthesis of Dimethyl decanedioate).
Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application In Synthesis of Dimethyl decanedioate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics