Catalytic Asymmetric Synthesis of Quaternary Barbituric Acids was written by del Pozo, Sandra;Vera, Silvia;Oiarbide, Mikel;Palomo, Claudio. And the article was included in Journal of the American Chemical Society in 2017.Recommanded Product: Diethyl isobutylmalonate This article mentions the following:
The catalytic asym. α-functionalization of prochiral barbituric acids, a subtype of pseudosym. 1,3-diamides, to yield the corresponding 5,5-disubstituted (quaternary) derivatives remains essentially unsolved. In this study 2-alkylthio-4,6-dioxopirimidines are designed as key 1,3-diamide surrogates that perform exceedingly in amine-squaramide catalyzed C-C bond forming reactions with vinyl ketones or Morita-Baylis-Hillmann-type allyl bromides as electrophiles. Mild acid hydrolysis of adducts affords barbituric acid derivatives with an in ring quaternary carbon in unprecedented enantioselectivity, offering valuable materials for biol. evaluations. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4Recommanded Product: Diethyl isobutylmalonate).
Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: Diethyl isobutylmalonate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics