Conformationally-restricted vigabatrin analogs as irreversible and reversible inhibitors of γ-aminobutyric acid aminotransferase was written by Pan, Yue;Calvert, Kristi;Silverman, Richard B.. And the article was included in Bioorganic & Medicinal Chemistry in 2004.Electric Literature of C10H16O2 This article mentions the following:
Compounds that inhibit γ-aminobutyric acid aminotransferase exhibit anticonvulsant activity; vigabatrin is a known irreversible inhibitor of this enzyme and anticonvulsant drug. Conformationally-restricted, five-membered- and six-membered-ring vigabatrin analogs were synthesized and tested as inhibitors of γ-aminobutyric acid aminotransferase. Two monofluorinated compounds, I (R1 = F, R2 = H; R1 = H, R2 = F), are time-dependent inhibitors of the enzyme, and their potencies are comparable to that of vigabatrin. II (R1 = NH2, R2 = H; R1 = H, R2 = NH2) are weak reversible inhibitors. In the experiment, the researchers used many compounds, for example, Ethyl 4-methylenecyclohexanecarboxylate (cas: 145576-28-9Electric Literature of C10H16O2).
Ethyl 4-methylenecyclohexanecarboxylate (cas: 145576-28-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Electric Literature of C10H16O2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics