Potent Inhibitors of the Qi Site of the Mitochondrial Respiration Complex III was written by Bolgunas, Stephen;Clark, David A.;Hanna, Wayne S.;Mauvais, Patricia A.;Pember, Steve O.. And the article was included in Journal of Medicinal Chemistry in 2006.Category: esters-buliding-blocks This article mentions the following:
A series of azole-fused salicylamides, e.g. I (X, Y = N, CH; R = H, F3C), were prepared as analogs of antimycin and assayed for activity at complex III of the mitochondrial respiratory chain. The activity of these compounds approached that of antimycin in inhibitory potency and some showed growth reduction of Septoria nodorum in vitro. I (X = N; Y = CH; R = H) was shown to bind at the Qi site of complex III by red-shift titration of the bc1 complex. In the experiment, the researchers used many compounds, for example, Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1Category: esters-buliding-blocks).
Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics