Cu(I)-NHC-Catalyzed (2 + 3)-Annulation of Tetramic Acids with 2H-Azirines: Stereoselective Synthesis of Functionalized Hexahydropyrrolo[3,4-b]pyrroles was written by Rostovskii, Nikolai V.;Sakharov, Pavel A.;Novikov, Mikhail S.;Khlebnikov, Alexander F.;Starova, Galina L.. And the article was included in Organic Letters in 2015.Category: esters-buliding-blocks This article mentions the following:
A stereoselective and high-yield synthesis of hexahydropyrrolo[3,4-b]pyrroles I [R1 = PMB, H, Bn, Ph, Ac, etc.; R2 = H, Me; R1R2 = (CH2)3; R3 = Ph, 4-ClC6H4, 4-OMeC6H4, CO2Me, 2-thienyl; R4 = 4-MeC6H4, 4-OMeC6H4, 4-NO2C6H4, Ph; R5 = H, Me, Ph] from tetramic acids and 2H-azirines under Cu(I)-NHC catalysis is developed. An unusual N-C2 azirine bond cleavage, initiated by a copper enolate, was rationalized in terms of a free radical reaction mechanism. In the experiment, the researchers used many compounds, for example, Methyl 2-thienylacetate (cas: 19432-68-9Category: esters-buliding-blocks).
Methyl 2-thienylacetate (cas: 19432-68-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics