Mahato, Sanjit K. published the artcileIridium(III)-Catalyzed Direct Intermolecular Chemoselective α-Amidation of Masked Aliphatic Carboxylic Acids with Dioxazolones via Nitrene Transfer, Product Details of C8H14O4, the publication is ACS Catalysis (2021), 11(12), 7126-7131, database is CAplus.
The Ir(III)-catalyzed direct α-C-H amidation of imidazole-masked aliphatic carboxylic acids I [R = H, Me; R1 = n-Bu, cyclopentylmethyl, 4-bromophenyl, 1H-indol-3-ylmethyl, etc.; RR1 = -(CH2)3-, -(CH2)4-] with dioxazolones II (R2 = n-Pr, 4-bromophenyl, 2-phenylethyl, furan-2-yl, etc.) for the preparation of amidated imidazoles III is reported. The presence of an imidazole moiety as a directing group is a key to the success of the reaction. The products III (R = H; R1 = n-Bu; R2 = Ph) can be easily converted to N-(1-oxo-1-(pentylamino)hexan-2-yl)benzamide and N-((1,1,1,3,3,3-hexafluoropropan-2-yl)oxy)benzamide in a simple procedure. The reaction shows a broad substrate scope for various substituted 2-acylimidazoles I, as well as a variety of dioxazolone derivatives II with important functional groups being tolerated. The reaction mechanism was investigated by deuterium-labeling experiments, Hammett plots, NMR, and FAB-MS, and propose the generation of an iridium nitrene intermediate.
ACS Catalysis published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C8H14O4, Product Details of C8H14O4.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics