Borrelli, S. published the artcileDelayed and recurrent dimethyl fumarate induced-lymphopenia in patients with multiple sclerosis, HPLC of Formula: 624-49-7, the publication is Multiple Sclerosis and Related Disorders (2022), 103887, database is CAplus and MEDLINE.
Early lymphopenia is a known side effect of di-Me fumarate, a disease-modifying therapy for MS. However, the long-term effects on immune response and the impact on lymphocyte counts when another disease-modifying treatment is introduced, remain unknown. To better understand these specific aspects, we reviewed cases that develop prolonged grade 2 to 4 lymphopenia under di-Me fumarate in Lausanne MS clinic. Retrospective anal. of the 12 patients (10.1%) who discontinued di-Me fumarate because of prolonged lymphopenia amongst the 119 patients treated with di-Me fumarate. We reviewed their demographics, as well as their clin., biol. and MRI characteristics compared to the non-lymphopenic patients, during di-Me fumarate therapy, and within a timeframe of up to 18 mo after switching to another disease-modifying treatment. We also focused on lymphocyte subsets in a subgroup of patients. Compared to non-lymphopenic patients, lymphopenic patients were older at di-Me fumarate initiation (51.4 yo vs 39.7, p = 0.0003) and the majority were male (p = 0.037). Three of them (25%) developed delayed lymphopenia, more than one year after treatment onset. Despite persistent lymphopenia, three patients experienced disease activity. Amongst the nine patients (75%) who were switched to another therapy, five (55.6%) presented recurrent lymphopenia, predominantly with a CD8+ T cell decrease. Di-Me fumarate has a long-term impact on lymphocyte biol., even after its discontinuation, with a sustained reduction in CD8+ T cells that may increase opportunistic infection risk, and should be taken in consideration when switching therapies after di-Me fumarate.
Multiple Sclerosis and Related Disorders published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, HPLC of Formula: 624-49-7.
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