Reetz, Manfred T.’s team published research in Angewandte Chemie in 91 | CAS: 5340-78-3

Reetz, Manfred T. published the artcileGeneral synthesis of active antiviral α-adamantyl carbonyl compounds, Safety of Ethyltert-butylacetate, the publication is Angewandte Chemie (1979), 91(1), 78-9, database is CAplus.

Silyl enol ethers R¹(Me₃SiO)C:CR²R³ [R¹ = MeO, Et, Me₂CH, EtO, Me₃C, R² = H, Me, Et, Me₃C, R¹R² = (CH₂)_n (n = 3, 4, 6), (CH₂)₂CHMeCH₂; R³ = H, Me] and 1-(trimethylsilyloxy)-4-methyl-3,4-dihydronaphthalene, easily obtained from R¹COCHR²R³ and Me₃SiCl, reacted with 1-bromoadamantane and TiCl₄ at -40 to -50° to give 62-89% α-adamantyl ketones I, useful as virucides. I (R¹R² = CH₂CH₂CHMeCH₂, R³ = H) was 3 times as active against the virus of Newcastle disease as 1-aminoadamantane, but only half as toxic.

Angewandte Chemie published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Safety of Ethyltert-butylacetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics