Zeng, Li-Yan published the artcileO-Methylation of carboxylic acids with streptozotocin, Quality Control of 103-26-4, the publication is Organic & Biomolecular Chemistry (2022), 20(26), 5230-5233, database is CAplus and MEDLINE.
The clin. used DNA-alkylating drug streptozotocin (STZ) was investigated using a simple work-up as an O-methylating agent to transform various carboxylic acids RC(O)OH (R = 2-phenylethenyl, 2-(4-chlorophenyl)ethenyl, 3-(1H-indol-3-yl)propyl, etc.), sulfonic acids R1S(O)2OH (R1 = Ph, 4-methoxyphenyl, 4-chlorophenyl) and phosphorus acids (R2)2P(O)OH (R2 = Ph, OPh) into corresponding Me esters RC(O)OMe, R1S(O)2OMe, (R2)2P(O)OMe and obtained with yields of up to 97% in 4 h at room temperature Good substrate tolerance was observed, and benefited from the mild conditions and compatibility of the reaction with water.
Organic & Biomolecular Chemistry published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C8H6N2O3, Quality Control of 103-26-4.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics