Moghadam, S. Arbabi published the artcileCell death and survival due to cytotoxic exposure modelled as a two-state Ising system, Quality Control of 55981-09-4, the main research area is Ising system cell death survival cytotoxic exposure; Ising model; bystander effect; cancer cell response; cytotoxicity; phase transition.
Cancer chemotherapy agents are assessed for their therapeutic utility primarily by their ability to cause apoptosis of cancer cells and their potency is given by an IC50 value. Chemotherapy uses both target-specific and systemic-action drugs and drug combinations to treat cancer. It is important to judiciously choose a drug type, its dosage and schedule for optimized drug selection and administration. Consequently, the precise math. formulation of cancer cells’ response to chemotherapy may assist in the selection process. In this paper, we propose a math. description of the cancer cell response to chemotherapeutic agent exposure based on a time-tested phys. model of two-state multiple-component systems near criticality. We describe the Ising model methodol. and apply it to a diverse panel of cytotoxic drugs administered against numerous cancer cell lines in a dose- response manner. The analyzed dataset was generated by the Netherlands Translational Research Center B.V. (Oncolines). This approach allows for an accurate and consistent anal. of cytotoxic agents’ effects on cancer cell lines and reveals the presence or absence of the bystander effect through the interaction constant By calculating the susceptibility function, we see the value of IC50 coinciding with the peak of this measure of the system’s sensitivity to external perturbations.
Royal Society Open Science published new progress about Cell death. 55981-09-4 belongs to class esters-buliding-blocks, name is 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, and the molecular formula is C12H9N3O5S, Quality Control of 55981-09-4.
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