Guanabens, Nuria published the artcileTartrate-resistant acid phosphatase 5b, but not periostin, is useful for assessing Paget’s disease of bone, Synthetic Route of 55981-09-4, the main research area is Pagets disease bone osteoarthritis TRAPb periostin; Bone turnover markers; Paget’s disease of bone; Periostin; TRAP5b.
To analyze if circulating periostin is a biomarker for PDB, and if it is associated with disease activity and involvement of long bones that represent major cortical contribution. Also, to analyze whether TRAP5b, a scarcely explored bone resorption marker, is useful in the assessment of PDB. No significant differences were observed between patients with and without active disease (964.5 ± 168.8 vs.1051.6 ± 175.6 pMol/L, p = 0.143), involvement or not of long bones (1022.2 ± 145.8 vs 949.7 ± 198.2 pMol/L, p = 0.181) and monostotic or polyostotic disease (963.8 ± 198.7 vs 1002.2 ± 161.4 pMol/L, p = 0.505). There were significant correlations between serum periostin and all bone turnover markers (bone ALP, PINP, uNTX, sCTX and TRAP5b) in PDB patients with active disease, but not in the inactive PDB group. Serum TRAP5b was significantly higher in PDB patients than in controls (4.43 ± 1.76 vs. 3.21 ± 1.02 U/L, p < 0.001), in those with active disease (4.98 ± 1.76 vs. 3.07 ± 0.72 U/L, p < 0.001) and in patients with polyostotic disease than in those with monostotic disease (4.81 ± 1.79 vs 3.68 ± 1.5 U/L, p = 0.005). TRAP5b levels were not influenced by previous bisphosphonate treatment (4.14 ± 1.42 vs. 4.84 ± 2.02 U/L, p = 0.206). Periostin is not useful for assessing PDB, while TRAP5b, which has been a scarcely explored bone turnover marker until now, may be useful in the anal. of this disease, providing new information on the resorption process. States. Bone (New York, NY, United States) published new progress about Biomarkers. 55981-09-4 belongs to class esters-buliding-blocks, name is 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, and the molecular formula is C12H9N3O5S, Synthetic Route of 55981-09-4.
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