Reuter, Hans published the artcileGuanosine nucleolipids: Synthesis, characterization, aggregation and X-Ray crystallographic identification of electricity-conducting G-ribbons, Safety of Ethyl 4-oxopentanoate, the main research area is glioblastoma cytotoxic guanosine nucleolipid synthesis aggregation crystallog; cytotoxic activity; drug profiling; glioblastoma; guanosine; nucleolipids; self-assembly; synthesis design.
The lipophilization of β-D-riboguanosine (1) with various sym. as well as asym. ketones is described (→3a-3f). The formation of the corresponding O-2′,3′-ketals is accompanied by the appearance of various fluorescent byproducts which were isolated chromatog. as mixtures and tentatively analyzed by ESI-MS spectrometry. The mainly formed guanosine nucleolipids were isolated and characterized by elemental analyses, 1H-, 13C-NMR and UV spectroscopy. For a drug profiling, static topol. polar surface areas as well as 10logPOW values were calculated by an increment-based method as well as exptl. for the systems 1-octanol-H2O and cyclohexane-H2O. The guanosine-O-2′,3′-ketal derivatives 3b and 3a could be crystallized in (D6)DMSO – the latter after one year of standing at ambient temperature X-ray anal. revealed the formation of self-assembled ribbons consisting of two structurally similar 3b nucleolipid conformers as well as integrated (D6)DMSO mols. In the case of 3a · DMSO, the ribbon is formed by a single type of guanosine nucleolipid mols. The crystalline material 3b · DMSO was further analyzed by differential scanning calorimetry (DSC) and temperature-dependent polarization microscopy. Crystallization was also performed on interdigitated electrodes (Au, distance, 5μm) and visualized by SEM. Resistance and amperage measurements clearly demonstrate that the electrode-bridging 3b crystals are elec. conducting. All O-2′,3′-guanosine ketals were tested on their cytostatic/cytotoxic activity towards phorbol 12-myristate 13-acetate (PMA)-differentiated human THP-1 macrophages as well as against human astrocytoma/oligodendroglioma GOS-3 cells and against rat malignant neuroectodermal BT4Ca cells.
Chemistry & Biodiversity published new progress about Aggregation. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Safety of Ethyl 4-oxopentanoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics