Barnes, Christopher published the artcileOrigins of N-formylmethamphetamine and N-acetylmethamphetamine in methamphetamine produced by the hydriodic acid and red phosphorus reduction of pseudoephedrine, Synthetic Route of 140-11-4, the main research area is forensic pseudoephedrine hydriodic acid red phosphorus methamphetamine.
FMA and AMA are suspected to be trace byproducts in methamphetamine (MA) produced from pseudoephedrine using the Nagai reaction. FMA is an intermediate in the synthesis of MA using the Leuckart reaction. However, as there is the possibility that FMA is a byproduct of the Nagai reaction, the significance of FMA as an indicator of the Leuckart reaction has been debated. It is therefore important to establish whether AMA and especially FMA are byproducts of the Nagai reaction and thus establish their significance as synthetic route markers. From the work presented here, FMA is a byproduct of the Nagai reaction but the mechanism by which FMA arises could be not determined AMA was also shown to be a byproduct of the Nagai reaction, most likely due to reaction between MA and phenyl-2-propanone (P-2-P), itself a byproduct of the Nagai reaction. Furthermore, during GC anal. of Nagai reaction products, MA has been shown to react with P-2-P or Et acetate in the injector to form AMA. Caution is recommended if the relative abundance of AMA and/or FMA are used as a basis for determining whether MA samples have a common source or not. Furthermore, it is clear that FMA cannot be considered to be a route-specific byproduct for the Leuckart reaction – it is the abundance of FMA in a reaction mixture or profile, not simply its presence, that points to the involvement of the Leuckart reaction.
Forensic Chemistry published new progress about Acetylation. 140-11-4 belongs to class esters-buliding-blocks, name is Benzyl acetate, and the molecular formula is C9H10O2, Synthetic Route of 140-11-4.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics