Sreedevi, Adikay published the artcilePhytochemical analysis and pharmacological evaluation of ethanol extract of fruits of Grewia tiliaefolia for nephroprotective activity, Quality Control of 41114-00-5, the main research area is Grewia fruit extract phytochem nephroprotective.
The present study was undertaken to screen the phytochems. present in fruits of Grewia tiliaefolia and to evaluate the potential role of these fruits in the amelioration of cisplatin-induced nephrotoxicity in male Albino rats. Ethanol extract of Fruits of Grewia tiliaefolia was prepared by hot extraction method. The prepared ethanol extract was subjected to preliminary phytochem. evaluation followed by TLC, HPTLC, HPLC and GC-MS anal. The nephroprotective potential of the extract was screened at 200 and 400mg/kg b. w. in both curative and prophylactic regimens in male Albino rats. Nephrotoxicity was induced by single i.p. injection of cisplatin at a dose of 5 mg/kg b.w. The nephroprotective activity was assessed by determining serum markers, urinary parameters, lipid peroxidation and antioxidant levels and his to pathol. studies in renal tissue. Upon preliminary phytochem. screening, the ethanol extract showed the presence of Proteins, flavonoids, Tannins, Terpenoids. HPTLC anal. resulted in a fingerprint of extract showing the presence of 14 compounds TLC and HPLC revealed the presence of quercetin, and GC-MS anal. showed the presence of 80 different phytochems. Pharmacol. studies revealed that administration of extract significantly attenuated the cisplatin- induced nephrotoxicity remarkably by restoring the biochem. and oxidative stress markers in both curative and prophylactic regimens in dose-dependent manner. Thus, the findings of the present study provided the phytochem. profile and validated the ethnomedicinal use of fruits of Grewia tiliaefolia as a renoprotective agent.
International Journal of Pharmaceutical Sciences and Research published new progress about Antioxidants. 41114-00-5 belongs to class esters-buliding-blocks, name is Ethyl pentadecanoate, and the molecular formula is C17H34O2, Quality Control of 41114-00-5.
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