El-Nashar, Heba A. S. published the artcileChemical composition, cytotoxic and anti-arthritic activities of hexane extracts of certain Schinus species, Safety of Methyl docosanoate, the main research area is chem composition cytotoxic anti arthritic hexane extract Schinus species.
The genus Schinus (Anacardiaceae) comprises about 29 species that are utilized in both traditional and current medicine to alleviate various disorders such as rheumatism, bronchial infections, stomach upset, menstrual disturbance, bronchitis, and conjunctivitis. In this study we aimed to investigate the chem. composition of hexane extracts obtained from Schinus polygamous and Schinus terebinthifolius leaves as well as their cytotoxic and anti-arthritic activities. The GC-MS anal. of S. polygamus leaves revealed identification of fifty-five components: being betulin (6.54%), phytol acetate (5.27%), lupeol (3.96%), palmitic acid Me ester (3.58%) and heptacosane (3.25%). While, seventeen compounds were identified in S. terebinthifolius leaves, predominately characterized by phytol (14.70%), lupeol (13.33%), linolenic acid Me ester (11.17%), palmitic acid Me ester (7.74%), and 28-oxours-12-en-3-yl acetate (7.44%). Both extracts showed moderate cytotoxic activities against hepatocellular carcinoma cells with IC50 values of 102.65 and 65.55μg/mL, resp. While colorectal carcinoma cell line presented IC50 values of 217.78 and 83.55μg/mL, resp. Further, both extracts provided moderate anti-arthritic effects (IC50: 80.12 and 63.09μg/mL, resp.) using protein denaturation test, compared to diclofenac sodium (IC50 = 15.12μg/mL).
Journal of Pharmacy and Pharmacology (Wilmington, DE, United States) published new progress about Antiarthritics. 929-77-1 belongs to class esters-buliding-blocks, name is Methyl docosanoate, and the molecular formula is C23H46O2, Safety of Methyl docosanoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics