Abdel Raoof, Gehan F. published the artcileCytotoxic effect and phytochemical study of petroleum ether extract of Tilia cordata mill, SDS of cas: 110-42-9, the main research area is Tilia petroleum ether extract anticancer cytotoxicity cancer.
Objective: The aim of this research was to investigate the chem. composition of petroleum ether extract of Tilia cordata aerial parts as well as to evaluate its cytotoxic activity. Methods: Gas chromatog. and gas chromatog.-mass spectrometry (GC-MS) were used to analyze the unsaponifiable matter and fatty acid Me esters. Moreover, the cytotoxicity was examined against human hepatoma HepG2 cell line and breast adenocarcinoma MCF cell line. Results: The result showed that thirteen compounds were identified in the fatty acid Me esters fraction representing 93.71% of the total identified peak area. The major compounds were Octadecanoic acid Me ester (36.26%) and eicosanoic acid Me ester (29.42%), whereas nineteen compounds in the unsaponifiable fraction were identified representing 90.56 % of the total beak area. The major compounds were 1-Nonene (30.44%), 1-Hexadecene (24.83%) and phytol (10.40%). Moreover, petroleum ether extract showed a potent cytotoxic effect against human hepatoma HepG2 cell line and a moderate cytotoxic effect on breast adenocarcinoma MCF7 human tumor cell line. Conclusion: So the current research aims to be the first step toward the use of petroleum ether extract of Tilia cordata aerial parts as a potent cytotoxic drug.
Universal Journal of Pharmaceutical Research published new progress about Antitumor agents. 110-42-9 belongs to class esters-buliding-blocks, name is Methyl decanoate, and the molecular formula is C11H22O2, SDS of cas: 110-42-9.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics