Olvera-Guillen, Roberto published the artcileSupramolecular poly(vinyl alcohol)-folate structure as functional layer and colloidal stabilizer of poly(vinyl acetate) nanoparticles with potential use as nanocarrier for hydrophobic antitumor agents, Formula: C24H14Cl2O7, the main research area is polyvinyl alc acetate folate nanoparticle stabilizer hydrophobic antitumor agent.
Poly(vinyl acetate) nanoparticles 50 ± 20 nm in diameter were synthesized by emulsion polymerization using poly(vinyl alc.) (PVA) as stabilizer, loaded with eugenol and phys. functionalized with folate in a post-reaction step. Interfacial tension and zeta potential measurements were done to provide evidence about the association between PVA and folate. In order to obtain the target particle size, the effect of the PVA molar mass on the colloidal stability of the latex was studied. The cytotoxic effect of these NPs was evaluated in vitro in the breast triple-neg. cancer cell line MDA-MB-231, and an apoptosis/necrosis assay by flow cytometry was carried out. The capability of the nanocarrier to increase the production of reactive oxygen species in cancer cells was determined by flow cytometry. Nanotoxicol. assessments of the NPs revealed that unloaded NPs were not cytotoxic, that functionalized-loaded NPs induced a decrease in cell viability by up to 70%, and that they induced apoptosis of breast cancer cells due to oxidative stress damage. Cytotoxicity significantly decreased in the absence of folate, suggesting the success of the phys. functionalization in the receptor-mediated drug delivery mechanism.
Journal of Nanoparticle Research published new progress about Antitumor agents. 2044-85-1 belongs to class esters-buliding-blocks, name is 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate, and the molecular formula is C24H14Cl2O7, Formula: C24H14Cl2O7.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics