Liu, Yingxin published the artcileOne-pot synthesis of pyrrolidone derivatives via reductive amination of levulinic acid/ester with nitriles over Pd/C catalyst, Application In Synthesis of 539-88-8, the main research area is levulinic acid reductive amination palladium pyrrolidone one pot synthesis.
The selective reductive amination of levulinic acid (LA) into pyrrolidone derivatives is regarded as one of the most promising reactions in the fields of biomass conversion into high value-added chems. Herein, we report a one-pot synthesis of N-substituted-5-methyl-2-pyrrolidones by reductive amination of LA/ester with nitriles over several com. catalysts. Among the catalysts tested, Pd/C was found to be the most efficient for the reductive amination of LA/ester with various nitriles to give high yields of pyrrolidones (up to 92%) under mild reaction conditions (80°C, 1.6 MPa H2, THF solvent). And the catalyst showed good reusability.
Reaction Kinetics, Mechanisms and Catalysis published new progress about Activation energy. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Application In Synthesis of 539-88-8.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics