Nogueira, Patricia Franklin Mayrink published the artcileThe aspect ratio of gold nanorods as a cytotoxicity factor on Raphidocelis subcaptata, Application of 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate, the main research area is gold nanorods cytotoxicity factor Raphidocelis subcaptata; Aspect ratio; Cytotoxicity; Gold nanorods; Oxidative stress; Raphidocelis subcaptata.
Gold nanorods (AuNRs) are promising nanoscale materials for several technol. and biomedical applications. The physicochem. properties of AuNRs, including size, shape and surface features, are crucial factors affecting their cytotoxicity. In this study, we investigated the effects of different aspect ratios of AuNRs (1.90, 2.35, 3.25 and 3.50) at concentrations of 2 and 10μg mL-1 on their cytotoxicity and cellular uptake in green algae Raphidocelis subcaptata. The experiment was performed in oligotrophic freshwater medium in a growth chamber with constant agitation of 80 rpm under controlled conditions (120μEm-2s-1 illumination; 12:12h light dark cycle and constant temperature of 22 ± 2°C). The algal growth was monitored daily for 96 h via electronic absorbance scanning at 600-750 nm. Oxidative stress, cell viability and autofluorescence were evaluated using a flow cytometer. Oxidative stress quantified by loading cultures with the fluorescent dye 2′, 7′-dichlorofluorescein diacetate. To assess algal cell viability, propidium iodide was selected as the fluorescent probe. Our results indicated that the aspect ratio of AuNRs mediates their biol. effects in green algae R. subcaptata. A pos. correlation between oxidative stress and increase of aspect ratio was found at concentration of 10μg mL-1. Higher cytotoxicity and mortality were observed for algae incubated with higher aspect ratios AuNRs (3.50).
Environmental Research published new progress about Aquatic environment. 2044-85-1 belongs to class esters-buliding-blocks, name is 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate, and the molecular formula is C24H14Cl2O7, Application of 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate.
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