Nidiry, Eugene Sebastian J. published the artcileTherapeutic indices of some antifungal organic compounds, Computed Properties of 140-11-4, the main research area is antifungal agent.
The objective of the study was to evaluate the therapeutic indexes (TIs) some antifungal organic compounds and to compare their safety. TIs of 55 organic compounds were evaluated by dividing their mammalian toxicity values given as median LDs ([mg/kg] rat, oral) collected from literature by exptl. determined fungitoxicity values evaluated as median effective concentration (EC50 [mg/L]) for the mycelial growth inhibition of Colletotrichum gloeosporioides on potato dextrose agar medium. Large variations in TIs are observed in different classes of compounds, namely, alcs., carboxylic acids, phenols, esters, and aldehydes. The relationship between carbon chain length of saturated monohydric alcs. and mammalian toxicity shows that toxicity increases from chain length 1 to 5, declines from 5 to 6, increases from 6 to 7, and steadily declines from 7 to 10. Thus, the relationship is by and large parabolic. The relationship between carbon chain length and molar antifungal activity is also parabolic. In spite of this, large differences are found in TIs making 1-decanol (TI = 42.1) a very safe antifungal compound and 1-pentanol (TI = 0.17) a hazardous antifungal compound This is because mammalian toxicity reaches a maximum around carbon chain length of 5, while in the case of antifungal activity, it reaches a maximum around carbon chain length of 10. Among the 55 compounds, whose TIs were evaluated, some compounds with high TIs (>10) which can be considered safe as antifungal compounds are citronellol, geraniol, 1-decanol, 1-octanol, Ph acetaldehyde, Me anthranilate, 1-naphthol, 2-naphthol, and propionic acid. Some compounds with low TIs (<0.50) which can be considered hazardous as antifungal compounds are resorcinol, hydroquinone, oxalic acid, and acetyl acetone. Asian Journal of Pharmaceutical and Clinical Research published new progress about Alcohols Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 140-11-4 belongs to class esters-buliding-blocks, name is Benzyl acetate, and the molecular formula is C9H10O2, Computed Properties of 140-11-4.
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