Voelkl, Matthias published the artcilePristine and artificially-aged polystyrene microplastic particles differ in regard to cellular response, Application In Synthesis of 2044-85-1, the main research area is microplastic particle cellular response cytotoxicity; Biological effects; Cytotoxicity; Fragments; Genotoxicity; Inflammation; Microplastic; RNA sequencing; Reactive oxygen species; Transcriptomic; Weathered particles.
Microplastic particles (MP), arising from the gradual decomposition of plastics in the environment, have been identified as a global problem. Most investigations of MP cytotoxicity use pristine spherical particles available from com. sources when evaluating their impact on mammalian cells, while only limited data is available for the more relevant “”weathered microplastic””. In this study, we exposed murine macrophages to polystyrene MP either after up to 130 days of accelerated ageing or in pristine condition. Weathered and pristine MP were physicochem. characterized, and their cytotoxicity was investigated using biol. assays, transcriptome anal., and metabolic pathways prediction. Whereas the response to pristine MP is mainly dominated by a TNF-α release, sharp-edged weathered MP induce broader adverse cellular reactions. This study stresses the importance of including more realistic test particles (e.g., weathered particles) in combination with a broad range of biol. assays when evaluating the potential risk of microplastic exposure.
Journal of Hazardous Materials published new progress about BMF proteins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2044-85-1 belongs to class esters-buliding-blocks, name is 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate, and the molecular formula is C24H14Cl2O7, Application In Synthesis of 2044-85-1.
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