Yancheva, Denista published the artcileSynthesis, crystal structure and biological activity screening of novel N-(α-bromoacyl)-α-amino esters containing valyl moiety, SDS of cas: 10047-10-6, the main research area is bromoacyl amino ester valyl synthesis crystal structure drug screening; peptide coupling antiinflammatory antibacterial antitumor agent cytotoxicity.
Three novel N-(α-bromoacyl)-α-amino esters: Me 2-(2-bromo-3-methylbutanamido)pentanoate, Me 2-(2-bromo-3-methylbutanamido)-2-phenylacetate and Me 2-(2-bromo-3-methylbutanamido)-3-phenylpropanoate were synthesized. Single crystal X-ray diffraction data are reported for compounds Me 2-(2-bromo-3-methylbutanamido)pentanoate and Me 2-(2-bromo-3-methylbutanamido)-2-phenylacetate. The cytotoxicity, anti-inflammatory and antibacterial activity of compounds bromoacyl amino esters were investigated. Addnl., the physico-chem. properties of studied compounds were calculated and an in silico toxicol. study of compounds the amino esters was performed. The low level of cytotoxicity and absence of antibacterial and anti-inflammatory activity of N-(α-bromoacyl)-α-amino esters in tested concentrations might be a beneficial prerequisite for their incorporation in prodrugs.
Acta Chimica Slovenica published new progress about Anti-inflammatory agents. 10047-10-6 belongs to class esters-buliding-blocks, name is Methyl 2-aminopentanoate hydrochloride, and the molecular formula is C6H14ClNO2, SDS of cas: 10047-10-6.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics