Are all aspirins really alike? A comparison of gastric ulcerogenicity with bioefficacy in rats was written by Rainsford, K. D.;Whitehouse, M. W.. And the article was included in Pharmacological Research Communications in 1980.COA of Formula: C17H15NO5 The following contents are mentioned in the article:
Fifteen aspirin [50-78-2] formulations (including 11 com. types) and various other salicylate preparations were compared primarily for intrinsic gastric ulcerogenicity in cold stressed rats. Several buffered aspirins were notably just as ulcerogenic as aspirin suspensions. High Na+-containing aspirin formulations were the least ulcerogenic of those examined but also exhibited the shortest duration of action as antipyretics when assayed against yeast-induced fever in rats. Incorporation of
4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.COA of Formula: C17H15NO5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics