Dominguez, Eduardo published the artcileIntegrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes, Application In Synthesis of 50670-76-3, the publication is Nature Chemical Biology (2014), 10(2), 113-121, database is CAplus and MEDLINE.
Phenotypic screening is making a comeback in drug discovery as the maturation of chem. proteomics methods has facilitated target identification for bioactive small mols. A limitation of these approaches is that time-consuming genetic methods or other means are often required to determine the biol. relevant target (or targets) from among multiple protein-compound interactions that are typically detected. Here, the authors have combined phenotypic screening of a directed small-mol. library with competitive activity-based protein profiling to map and functionally characterize the targets of screening hits. Using this approach, the authors identify carboxylesterase 3 (Ces3, also known as Ces1d) as a primary mol. target of bioactive compounds that promote lipid storage in adipocytes. The authors further show that Ces3 activity is markedly elevated during adipocyte differentiation. Treatment of two mouse models of obesity-diabetes with a Ces3 inhibitor ameliorates multiple features of metabolic syndrome, illustrating the power of the described strategy to accelerate the identification and pharmacol. validation of new therapeutic targets.
Nature Chemical Biology published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Application In Synthesis of 50670-76-3.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics