Chiloeches, A. published the artcileBiobased polymers derived from itaconic acid bearing clickable groups with potent antibacterial activity and negligible hemolytic activity, Quality Control of 617-52-7, the publication is Polymer Chemistry (2021), 12(21), 3190-3200, database is CAplus.
Herein, the authors report, for the first time, the synthesis of clickable polymers derived from biobased itaconic acid, which was used for the preparation of novel cationic polymers with antibacterial properties and low hemotoxicity via click chem. Itaconic acid (IA) was subjected to chem. modification by incorporating clickable alkyne groups on the carboxylic acids. The resulting monomer with pendant alkyne groups was easily polymerized and copolymerized with di-Me itaconate (DMI) by radical polymerization The feed molar ratio of comonomers was varied to precisely tune the content of alkyne groups in the copolymers and the amphiphilic balance. Subsequently, an azide with a thiazole group, which is a component of the vitamin thiamine (B1), was attached onto the polymers by copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chem. leading to triazole linkages. N-Alkylation reactions of the thiazole and triazole groups with Me and Bu iodides provide the corresponding itaconate derivatives with pendant azolium groups. The copolymers with variable cationic charge densities and hydrophobic/hydrophilic balances, depending on the comonomer feed ratio, display potent antibacterial activity against gram-pos. bacteria, whereas the activity was almost null against gram-neg. bacteria. Hemotoxicity assays demonstrated that the copolymers exhibited negligible hemolysis and excellent selectivity, more than 1000-fold, for gram-pos. bacteria over human red blood cells.
Polymer Chemistry published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Quality Control of 617-52-7.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics