Lang, S. A. Jr. published the artcileβ-Aminocinnamonitriles as potential antiinflammatory agents, Category: esters-buliding-blocks, the publication is Journal of Medicinal Chemistry (1975), 18(4), 441-3, database is CAplus and MEDLINE.
Of 13 title compounds, prepared by the reaction of salts of acetonitrile [75-05-8] and propionitrile [107-12-0] with the appropriate arylnitrile, only the parent β-aminocinnamonitrile [1823-99-0] had activity comparable to aspirin [50-78-2] in the carrageenan-induced rat paw edema test. Of 7 aminoarylacrylonitriles, prepared by the reaction of arylcyanoacetaldehydes with formamide derivatives, and 5 phenylpropiolate derivatives, none showed antiinflammatory activity.
Journal of Medicinal Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Category: esters-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics