One-Pot Synthesis and Intramolecular Cyclization of 5-(Prop-2-ynylsulfanyl)-1H-pyrrol-2-amines: A Simple Approach to 2,7-Dihydrothiopyrano[2,3-b]pyrrol-6-amines was written by Nedolya, Nina A.;Tarasova, Olga A.;Albanov, Alexander I.;Trofimov, Boris A.. And the article was included in Synthesis in 2016.Formula: C4H7NS The following contents are mentioned in the article:
An expedient approach for the preparation of previously unknown 2,7-dihydrothiopyrano[2,3-b]pyrrol-6-amines I (R = Me, Et, Pr; RR = (CH2)4; R1 = Me, Et, i-Pr, n-Bu, etc.) from readily accessible starting materials (propargylamines, isothiocyanates, and propargyl bromide) has been developed. The methodol. is based on the one-pot synthesis and thermally-induced fast rearrangement of 5-(prop-2-ynylsulfanyl)-1H-pyrrol-2-amines into 2,7-dihydrothiopyrano[2,3-b]pyrrol-6-amines. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Formula: C4H7NS).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Formula: C4H7NS
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics