One-Pot Parallel Synthesis of 5-(Dialkylamino)tetrazoles was written by Savych, Olena;Kuchkovska, Yuliya O.;Bogolyubsky, Andrey V.;Konovets, Anzhelika I.;Gubina, Kateryna E.;Pipko, Sergey E.;Zhemera, Anton V.;Grishchenko, Alexander V.;Khomenko, Dmytro N.;Brovarets, Volodymyr S.;Doroschuk, Roman;Moroz, Yurii S.;Grygorenko, Oleksandr O.. And the article was included in ACS Combinatorial Science in 2019.Application In Synthesis of Isopropylisothiocyanate The following contents are mentioned in the article:
Two protocols for the combinatorial synthesis of 5-(dialkylamino)tetrazoles were developed. The best success rate (67%) was shown by the method that used primary and secondary amines, 2,2,2-trifluoroethylthiocarbamate, and sodium azide as the starting reagents. The key steps included the formation of unsym. thiourea, subsequent alkylation with 1,3-propane sultone and cyclization with azide anion. A 559-member aminotetrazole library was synthesized by this approach; the overall readily accessible (REAL) chem. space covered by the method exceeded 7 million feasible compounds This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Application In Synthesis of Isopropylisothiocyanate).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application In Synthesis of Isopropylisothiocyanate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics