Studies on effectiveness of diclofenac potassium was written by Yang, Fangju;Fang, Zhiping;Yang, Xiaomin;Zhang, Qi;Zhou, Suzhen. And the article was included in Huaxi Yaoxue Zazhi in 2000.Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:
The effectiveness and acute toxicity of diclofenac K (DK) manufactured in China were studied in rats and mice with carrageenin-induced paw edema and ear edema . DK (5-10 mg kg-1, oral) significantly inhibited carrageenin-induced paw edema and ear edema in rats and mice and also inhibited the pain in writhing model and hot plate method in mice. The LD50 for DK po in mice was (160.04 ± 43.49) mg kg-1 compared with that of (182.58 ± 30.64) mg.kg-1 for DK i.p. The results showed that the anti-inflammatory and analgesic effects of DK were better than those of benorilate. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate).
4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics