Identification of novel GPR81 agonist lead series for target biology evaluation was written by Davidsson, Oejvind;Nilsson, Kristina;Braanalt, Jonas;Andersson, Terese;Berggren, Kristina;Chen, Yantao;Fjellstroem, Ola;Graden, Henrik;Gustafsson, Linda;Hermansson, Nils-Olov;Jansen, Frank;Johannesson, Petra;Ohlsson, Bengt;Tyrchan, Christian;Wellner, Annika;Wellner, Eric;Oelwegaard-Halvarsson, Maria. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.Recommanded Product: 102-09-0 The following contents are mentioned in the article:
GPR81 is a novel drug target that is implicated in the control of glucose and lipid metabolism The lack of potent GPR81 modulators suitable for in vivo studies has limited the pharmacol. characterization of this lactate sensing receptor. We performed a high throughput screen (HTS) and identified a GPR81 agonist chem. series containing a central acyl urea scaffold linker. During SAR exploration two addnl. new series were evolved, one containing cyclic acyl urea bioisosteres and another a central amide bond. These three series provide different selectivity and physicochem. properties suitable for in-vivo studies. This study involved multiple reactions and reactants, such as Diphenyl carbonate (cas: 102-09-0Recommanded Product: 102-09-0).
Diphenyl carbonate (cas: 102-09-0) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 102-09-0
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics