Access to 3-Amino-[1,2,4]-triazolo Pyridines and Related Heterocycles via Electrochemically Induced Desulfurative Cyclization was written by Hu, Yunfei;Chen, Li;Zou, Canlin;He, Jiangtao;Feng, Luanqi;Wu, Jia-Qiang;Chen, Wen-Hua;Hu, Jinhui. And the article was included in Organic Letters in 2022.Reference of 2253-73-8 The following contents are mentioned in the article:
An efficient, one-pot approach was established for synthesizing a wide range of 3-amino-[1,2,4]-triazolo pyridines and related heterocycles from the electrochem. induced desulfurative cyclization of 2-hydrazinopyridines with isothiocyanates. The protocol allowed for the formation of C-N bonds under simple conditions without transition metals or external oxidants. The practicability of this strategy was demonstrated by its broad substrate scope, good functional group compatibility, and gram-scale synthesis. The late-stage modification of 3-amino-[1,2,4]-triazolo pyridines enabled to obtain several mols. with potent anticancer activity. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Reference of 2253-73-8).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Reference of 2253-73-8
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics