Absence of mutagenic activity of benorylate, paracetamol and aspirin in the Salmonella/mammalian microsome test was written by Jasiewicz, M. L.;Richardson, J. C.. And the article was included in Mutation Research Letters in 1987.Application of 5003-48-5 The following contents are mentioned in the article:
Benorylate [5003-48-5] and its 2 major hydrolysis products, paracetamol [103-90-2], and aspirin [50-78-2], were examined for mutagenicity in the Salmonella/mammalian microsome screening test. The compounds were tested in 6 strains of S. typhimurium in the presence and absence of a rat-liver microsome activation system. Benorylate did not show evidence of mutagenic activity, with or without metabolic activation, at 0.006-3 mg/plate. Paracetamol and aspirin likewise did not show any evidence of mutagenic activity at 0.1-50 and 0.01-50 mg/plate, resp. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Application of 5003-48-5).
4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application of 5003-48-5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics