Effect of indomethacin on the cyclic AMP-dependent protein kinase was written by Catalan, R. Edgardo;Aragones, Maria D.;Martinez, A. M.;Armijo, Manuel;Pina, Manuel. And the article was included in European Journal of Pharmacology in 1980.Safety of 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:
Indomethacin (I) [53-86-1] inhibited cyclic AMP-dependent protein kinase [9026-43-1] activity in small intestine in in vivo experiments An inverse pattern of variation was exhibited by acetylsalicylic acid [50-78-2], eterylate [62992-61-4], and benorylate [5003-48-5]; acetyl-p-aminophenol [103-90-2] was inactive. Indomethacin, acetylsalicylic acid, eterylate, and benorylate increased protein kinase activity in liver, lung, and heart. The in vivo effect of indomethacin was confirmed by in vitro experiments with small intestine and heart protein kinases. Indomethacin may affect protein kinase activity in a tissue-specific way. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Safety of 4-Acetamidophenyl 2-acetoxybenzoate).
4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Safety of 4-Acetamidophenyl 2-acetoxybenzoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics