Efficient synthesis of unsymmetrical trisubstituted 1,3,5-triazines catalyzed by hemoglobin was written by Li, Fengxi;Wang, Chunyu;Xu, Yaning;Zhao, Zixian;Su, Jiali;Luo, Chenhan;Ning, Yujie;Li, Zhengqiang;Li, Chen;Wang, Lei. And the article was included in Molecular Catalysis in 2021.Synthetic Route of C4H7NS The following contents are mentioned in the article:
In this work, a green and efficient process for the synthesis of unsym. trisubstituted 1,3,5-triazines from isothiocyanate with amidines and 1,1,3,3-tetramethylguanidine was developed. Under optimal conditions (isothiocyanate (0.1 mmol), amidines (0.1 mmol), 1,1,3,3-tetramethylguanidine (0.1 mmol), DMSO (1 mL), hemeprotein (heme concentration: 0.05 mol%), TBHP (3 equiv), room temperature, 10 min), high yields of 1,3,5-triazines (81%-96%) was obtained when HbRb (Hb from rabbit blood) was used as the catalyst. This enzymic method demonstrates the great potential for the synthesis of unsym. trisubstituted 1,3,5-triazines and extends the application of enzyme catalytic promiscuity in organic synthesis. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Synthetic Route of C4H7NS).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Synthetic Route of C4H7NS
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics