Efficient synthesis of unsymmetrical trisubstituted 1,3,5-triazines catalyzed by hemoglobin was written by Li, Fengxi;Wang, Chunyu;Xu, Yaning;Zhao, Zixian;Su, Jiali;Luo, Chenhan;Ning, Yujie;Li, Zhengqiang;Li, Chen;Wang, Lei. And the article was included in Molecular Catalysis in 2021.Category: esters-buliding-blocks The following contents are mentioned in the article:
In this work, a green and efficient process for the synthesis of unsym. trisubstituted 1,3,5-triazines from isothiocyanate with amidines and 1,1,3,3-tetramethylguanidine was developed. Under optimal conditions (isothiocyanate (0.1 mmol), amidines (0.1 mmol), 1,1,3,3-tetramethylguanidine (0.1 mmol), DMSO (1 mL), hemeprotein (heme concentration: 0.05 mol%), TBHP (3 equiv), room temperature, 10 min), high yields of 1,3,5-triazines (81%-96%) was obtained when HbRb (Hb from rabbit blood) was used as the catalyst. This enzymic method demonstrates the great potential for the synthesis of unsym. trisubstituted 1,3,5-triazines and extends the application of enzyme catalytic promiscuity in organic synthesis. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Category: esters-buliding-blocks).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics