Chen, Qi-xu et al. published their research in Zhejiang Huagong in 2021 | CAS: 5003-48-5

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Name: 4-Acetamidophenyl 2-acetoxybenzoate

Improved synthesis method of benorilate was written by Chen, Qi-xu;Zhang, Yong-chun;Ren, Ji-bo;Cao, Zhi-chao;Liu, Sheng-wei;Song, Zi-long;Qi, Qi;Wang, Ming-jun;Yuan, Wen-peng. And the article was included in Zhejiang Huagong in 2021.Name: 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

Benorilate is a non-steroidal anti-inflammatory, antipyretic and analgesic. Benorilate is widely used clin. because of its low irritation to the gastrointestinal tract, low toxicity and long action time. The existing synthesis method uses thionyl chloride/pyridine as the chlorination reagent, which has problems such as large pungent odor, complicated equipment and environmental pollution. By improving and optimizing the synthesis method, using Vilsmeier reagent/triethylamine as the chlorination reagent and DMF as the reaction solvent, the total yield of the reaction could reach 80.4%. The improved method has mild reaction conditions, low odor, simple equipment, less waste water and waste gas, and good product properties. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Name: 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Name: 4-Acetamidophenyl 2-acetoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics