Study on plasma levels of benorylate and its metabolites in man following single- and repeated administration was written by Cailleux, P.;Cailleux, A.;Allain, P.;Renier, J. C.. And the article was included in Therapie in 1979.Application of 5003-48-5 The following contents are mentioned in the article:
After administration of benorylate (I) [5003-48-5] (4 g, orally, once or 3 g, orally, twice/day) to healthy individuals, only I metabolites salicylic acid [69-72-7] and paracetamol [103-90-2] were determined in blood plasma. I was not found even though the sensitivity of the method used was 0.1 mg/L. Great intersubject variations in plasma levels and half-life values for I metabolites were observed both after single and double dose of I. After 1 dose of I, plasma levels of the metabolites varied from 14-74 mg/L and 1.8-9.8 mg/L, and individual half-life varied 10-20 h and 6-47 h for salicylic acid and paracetamol, resp. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Application of 5003-48-5).
4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application of 5003-48-5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics