Improvement of synthetic process of benorilate was written by Fu, Xiaozhong;Li, Ling;Rao, Guangling;Tang, Lei;Dong, Yongxi. And the article was included in Guiyang Yixueyuan Xuebao in 2012.Reference of 5003-48-5 The following contents are mentioned in the article:
Objective: To optimize the synthetic process of benorilate, and to obtain better exptl. teaching effect. Methods: The oxalyl chloride and DMF were used to substitute thionyl chloride and pyridine, and the reaction temperature and acetylsalicyloyl chloride distillation temperature were changed to observe the effect on the yield and quality of benorilate. Results: The oxalyl chloride and DMF reaction was rapid, the reaction condition was mild, and the yield was high. The product quality could be improved by reducing the reaction temperature and acetylsalicyloyl chloride distillation temperature Conclusion: The improved method can reduce drug dosage, experiment time and energy consumption and improve the yield and quality of the product. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Reference of 5003-48-5).
4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Reference of 5003-48-5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics