33993-24-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 33993-24-7, name is Cyclopropanecarboxylic anhydride belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Will contain water (0.32 ml) with trifluoroacetic acid (4.2 ml) cooled to -5 C the solution, and ethyl-N-[(mesitylsulfonyl)oxy]ethaneimidate (2.29 g, 8.02 mmol) blending and the stirring the mixture at room temperature for up to 1 hour. The reaction mixture with ice-water (20 ml) then mixes and with dichloromethane (20 ml) extraction. The sodium sulfate machine in on the drying and filtering, and the obtained solution for the 0 C dropwise to 5-bromo-4-methylpyridin-2-amine (1 g, 1.79 mmol) in dichloromethane (15 ml) in solution. The mixture stirred at room temperature for 1 hour and then with diethyl ether (20 ml) incorporation. The precipitated solid is filtered out of the diethyl ether is used for cleaning. The solid for drying under high vacuum. This produced 1.22 g (theoretical value of 57%) of the 1,2-diamino-5-bromo-4-methylpyridinium-2,4,6-trimethylbenzolsulfonate. The 1,2-diamino-5-bromo-4-methylpyridinium-2,4,6-trimethylbenzolsulfonate (580 mg, 1.44 mmol) and cyclopropylcarboxylic acid anhydride (1.33 g, 8.65 mmol) in pyridine (2.5 ml) in solution in 100 C stirring up to 8 hours. The reaction mixture is concentrated in the rotary evaporator and the residual substance is dissolved in DMSO/water/b in nitrile. By this solution the sealing ripoll filter filtering and by preparative HPLC (eluents: acetonitrile/water with 0.1% trifluoro acetic acid the gradient) to be purified. This generating 279 mg (theoretical value of 69%) the subject compound.
The synthetic route of 33993-24-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; ROEHN, ULRIKE; ELLERMANN, MANUEL; STRASSBURGER, JULIA; WENDT, ASTRID; ROEHRIG, SUSANNE; WEBSTER, ROBERTALAN; SCHMIDT, MARTINAVICTORIA; TERSTEEGEN, ADRIAN; BEYER, KRISTIN; SCHAEFER, MARTINA; BUCHMUELLER, ANJA; GERDES, CHRISTOPH; SPERZEL, MICHAEL; SANDMANN, STEFFEN; HEITMEIER, STEFAN; HILLISCH, ALEXANDER; ACKERSTAFF, JENS; TERJUNG, CARSTEN; (148 pag.)TW2016/5809; (2016); A;,
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