Identifying new lead structures to enhance tolerance towards drought stress via high-throughput screening giving crops a quantum of solace was written by Frackenpohl, Jens;Schneider, Linn;Decker, Luka J. B.;Dittgen, Jan;Fenkl, Franz;Fischer, Christian;Franke, Jana;Freigang, Joerg;Getachew, Rahel;Gonzalez Fernandez-Nino, Susana M.;Helmke, Hendrik;Hills, Martin J.;Hohmann, Sabine;Kleemann, Jochen;Kurowski, Karoline;Lange, Gudrun;Luemmen, Peter;Meyering, Nicole;Poree, Fabien;Schmutzler, Dirk;Wrede, Sebastian. And the article was included in Bioorganic & Medicinal Chemistry in 2019.SDS of cas: 2253-73-8 The following contents are mentioned in the article:
Novel synthetic lead structures interacting with RCAR/(PYR/PYL) receptor proteins were identified based on the results of a high-throughput screening campaign of a large compound library followed by focused SAR studies of the three most promising hit clusters. While indolinylmethyl sulfonamides 8y,z and phenylsulfonyl ethylenediamines 9y,z showed strong affinities for RCAR/ (PYR/PYL) receptor proteins in wheat, thiotriazolyl acetamides 7f,s exhibited promising efficacy against drought stress in vivo (wheat, corn and canola) combined with confirmed target interaction in wheat and arabidopsis thaliana. Remarkably, binding affinities of several representatives of 8 and 9 were on the same level or even better than the essential plant hormone abscisic acid (ABA). This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8SDS of cas: 2253-73-8).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.SDS of cas: 2253-73-8
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics