Synthesis of N-trifluoromethyl amides from carboxylic acids was written by Liu, Jianbo;Parker, Matthew F. L.;Wang, Sinan;Flavell, Robert R.;Toste, F. Dean;Wilson, David M.. And the article was included in Chem in 2021.Computed Properties of C4H7NS The following contents are mentioned in the article:
Here, the synthesis of N-trifluoromethyl amides R1C(O)NCF3(R2) [R1 = Et, cyclohexyl, CH2CH2Ph, etc.; R2 = Me, allyl, CH2CH2Ph, etc.] from carboxylic acid halides and esters under mild conditions via isothiocyanates in the presence of silver fluoride at room temperature was reported. Through this strategy, isothiocyanates were desulfurized with AgF, and then the formed derivative was acylated to afford N-trifluoromethyl amides, including previously inaccessible structures. This method showed broad scope, provides a platform for rapidly generating N-trifluoromethyl amides by virtue of the diversity and availability of both reaction partners and should find application in the modification of advanced intermediates. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Computed Properties of C4H7NS).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Computed Properties of C4H7NS
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics